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MDMA×Mephedrone
?︎ Unknown
No information available on whether effects are diminished or enhanced
☠️︎ Life Threatening
This combination is very dangerous and unsafe; it may cause significant harm, including physical damage, can trigger unpredictable reactions, and can be fatal!
Risk of serotonin syndrome (symptoms: confusion, muscle twitching, fever, and elevated heart rate; immediate medical treatment is required if suspected!) as both drugs raise serotonin levels. Stimulants also increase the neurotoxic effects of MDMA, in addition to concerns of high blood pressure and unnecessary strain on the heart. As well as potentially causing anxiety and greater physical discomfort due to the combination.
Sources:
[1] TripSit Database of Drug Combinations. https://combo.tripsit.me/
[2] J Kehr, F Ichinose, S Yoshitake, M Goiny, T Sievertsson, F Nyberg, T Yoshitake. Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats. https://doi.org/10.1111/j.1476-5381.2011.01499.x
[3] Gregory C. Hadlock, Katy M. Webb, Lisa M. McFadden, Pei Wen Chu, Jonathan D. Ellis, Scott C. Allen, David M. Andrenyak, Paula L. Vieira-Brock, Christopher L. German, Kevin M. Conrad, Amanda J. Hoonakker, James W. Gibb, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein. 4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse. https://doi.org/10.1124/jpet.111.184119
[4] Gough B, Ali SF, Slikker W Jr, Holson RR. . Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate. (1991). https://doi.org/10.1016/0091-3057(91)90137-q
[5] Schmidt CJ, Levin JA, Lovenberg W. . In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain. (1987). https://doi.org/10.1016/0006-2952(87)90729-5
[6] Bankson MG, Cunningham KA.. 3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions. (2001). https://pubmed.ncbi.nlm.nih.gov/11356903/
[7] A.C. Parrott. Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity (2002). https://doi.org/10.1016/S0091-3057(01)00711-0
[8] Lisa H. Gold & George F. Koob . MDMA produces stimulant-like conditioned locomotor activity. (1989). https://doi.org/10.1007/BF00445556
[9] Meng H, Cao J, Kang J, Ying X, Ji J, Reynolds W, Rampe D.. Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat . https://doi.org/10.1016/j.toxlet.2011.10.010