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Amphetamine×MDMA
?︎ Unknown
No information available on whether effects are diminished or enhanced
⚠️︎ Caution
This combination creates additional risks and may produce significant adverse effects.
This combination of stimulants will increase strain on the heart, may cause some physical discomfort, and has the chance to cause cardiovascular issues. The anxiogenic and focusing effects of stimulants can increase the chance of unpleasant thought loops and make the experience more uncomfortable, this combination raises these chances. Amphetamines will increase the neurotoxic effects of MDMA, in addition to causing further concerns of hyperthermia due to the inherent nature of the combination. It will also raise one's body temperature, also likely making the combination more neurotoxic.
Sources:
[1] TripSit Database of Drug Combinations. https://combo.tripsit.me/
[2] Kelly J. Clemens, Iain S. McGregor, Glenn E. Hunt, Jennifer L. Cornish. MDMA, methamphetamine and their combination: possible lessons for party drug users from recent preclinical research. https://doi.org/10.1080/09595230601036945
[3] Kelly J. Clemens, Iain S. McGregor, Glenn E. Hunt, Jennifer L. Cornish. Repeated weekly exposure to MDMA, methamphetamine or their combination: long-term behavioural and neurochemical effects in rats . https://doi.org/10.1016/j.drugalcdep.2006.06.004
[4] P. Leon Brown, Eugene A. Kiyatkin. Brain hyperthermia induced by MDMA (‘ecstasy’): modulation by environmental conditions. https://doi.org/10.1111/j.0953-816X.2004.03453.x