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Alcohol×Cocaine
↔️︎ Counteracting
Some effects weaken each other. This may risk consuming more than usual and underestimating the strain on body or mind.
⚠︎ Dangerous
This combination is dangerous and unsafe; it may cause significant adverse effects and physical harm.
Cocaine can decrease some of the intoxicating effects of alcohol, causing some people to drink more than they otherwise would, which leads to greater behavioral and physical health risks. There is also some debate about cocaethylene, a metabolite produced when combining alcohol and cocaine, with some researchers positing that it is more cardiotoxic than cocaine on its own. Use moderation when combining these substances.
Sources:
[1] TripSit Database of Drug Combinations. https://combo.tripsit.me/
[2] McCance-Katz, E. F., Kosten, T. R., & Jatlow, P. . Concurrent use of cocaine and alcohol is more potent and potentially more toxic than use of either alone—A multiple-dose study.. https://doi.org/10.1016/S0006-3223(97)00426-5
[3] Pergolizzi, J., Breve, F., Magnusson, P., LeQuang, J. A. K., & Varrassi, G.. Cocaethylene: When cocaine and alcohol are taken together. (2022). https://doi.org/10.7759/cureus.22498
[4] Shastry, S., Manoochehri, O., Richardson, L. D., & Manini, A. F. . Cocaethylene cardiotoxicity in emergency department patients with acute drug overdose.. https://doi.org/10.1111/acem.14584
[5] Wiener, S. E., Sutijono, D., Moon, C. H., Subramanian, R. A., Calaycay, J., Rushbrook, J. I., & Zehtabchi, S.. Patients with detectable cocaethylene are more likely to require intensive care unit admission after trauma. . https://doi.org/10.1016/j.ajem.2009.06.014